In comparison, fluorescent bioimaging is a real-time, non-invasive and radiation-free technology 21, 22. However, the key constraints of these tomographic techniques are their limited spatial resolution and long image imaging times, making them incapable of visualizing the real-time biodistribution and pharmacokinetics of microcarriers. To evaluate the delivery of the microcarrier and monitor the drug-release process in real time, biomedical imaging techniques such as position-emission tomography (PET) 18, photoacoustic imaging 19 and magnetic resonance imaging (MRI) 20 have been utilized. However, clinical translation can only be realized if the in vivo delivery of the microcarriers is perfectly evaluated, including the biodistribution, pharmacokinetics, drug-release behaviour, clearance route and toxicity. Compared with traditional therapeutic agents, microcarrier drug delivery systems including polymeric nanoparticles 6, 7, 8, liposome particles 9, 10, nanoemulsions 11 and mesoporous silica particles (MSP) 12, 13, 14, offer many attractive features, such as high loading capacities, efficient protection of bioactive drugs and high therapeutic indexes 15, 16, 17. Despite these advantages, most bioactive drugs, such as peptides and proteins, suffer from low bioavailability after oral administration because of their degradation or deactivation in harsh gastrointestinal (GI) environments 4, 5. Oral administration is by far the most convenient pathway for drug delivery because of its non-invasive nature, avoiding the pain and discomfort associated with injections as well as minimizing contaminations 1, 2, 3. These findings provide novel insights for the development of therapeutic and bioimaging strategies of orally administered drugs. Moreover, minimal deposition of the microcarriers is found in non-target organs, such as the liver, spleen and kidney. The microcarriers show a prolonged residence time of up to 72 h in the gastrointestinal tract, releasing up to 62% of their content. Significantly, we can track the microcarrier fate and semi-quantitatively monitor the content of drug released in vivo in real time by measuring the fluorescence signals in the second near-infrared window of lanthanide-based downconversion nanoparticles with an absorption competition-induced emission bioimaging system. Here, we report a novel microcarrier that can retain drugs and withstand the harsh conditions of gastrointestinal tract. Work more efficiently with LG's Office computer monitors that are ultra-clear and wide, offering true color contrast and detail at any angle.Non-invasive monitoring of gastrointestinal drug release in vivo is extremely challenging because of the limited spatial resolution and long scanning time of existing bioimaging modalities, such as X-ray radiation and magnetic resonance. The accurate diagnosis gets achieved with the top-notch image display that produces precise tissue level details to encourage the medical anatomy.Įnjoy High Performance with LCD LED Monitors high performance for dual work as well as play purpose. LG medical monitors come equipped with an array of functions to assist sharp and well managed medical treatment. Our 4K & 5K gaming monitors have an excellent resolution & high refresh rate to enhance the user experience. LG 5K monitors are a great option for gamers, photographers & graphic designers. With an in-place switching IPS monitor, you can experience stunning images from any angle. Learn more about LG's gaming monitors & their features.ĭiscover a richer, brighter, more detailed online experience. Discover the features that make LG's Ultragear an innovative collection, a game changer. Discover cutting-edge display technology and slim designs to give you a whole new outlook with monitors and other computer equipment from LG. From the broad, beautiful widescreen picture of our UltraWide monitor. We bring you crystal clarity in the perfect size and shape for your needs. Turn your home computer into a world of multimedia pleasure. You’ll get a new outlook on life with monitors and other computer monitors from LG. With an LG computer monitor you’ll discover cutting-edge display technology and slim designs, from our dazzling LED and LCD monitors, which offer state-of-the-art display and features. Discover computer monitors with slim designs, striking color and life-like motion for an optimal viewing experience. Expand your point of view with LG monitors that adapt to the needs of business users, gamers, graphic artists and multimedia enthusiasts alike.
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